Pharmaceutical Intermediates

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PMK ethyl glycidate

• Product NamePMK ethyl glycidate
• CAS28578-16-7
• MFC13H14O5
• MW250.25
• EINECS234-232-0
• MOL File28578-16-7.mol

Chemical Properties

Boiling point	327.8±42.0 °C(Predicted)
Density	1.302±0.06 g/cm3(Predicted)

Description

PMK ethyl glycidate is an analytical reference standard categorized as a precursor in the synthesis of methylenedioxy phenethylamines and amphetamines, including 3,4-MDMA. This product is intended for research and forensic applications.

Uses

NSC 195099 can be used as an analytical reference standard.

Synthesis

To a solution of piperonal (1, 3.00 g, 19.9 mmol) in CH2Cl2 (100 mL) was added (carbethoxyethylidene)triphenylphosphorane (2,14.5 g, 40.0 mmol), and the reaction mixture was stirred for 24 h at room temperature. The mixture was then concentrated at reduced pressure, and the residue was purified by flash column chromatography on silica gel (hexanes/EtOAc,10:1) to afford olefin 3 (4.45 g, 95%) as a colorless oil: 1H NMR (400 MHz, CDCl3) d 7.58 (s, 1H), 6.92 (d, J = 1.7 Hz, 1H), 6.90 (dd, J = 7.9, 1.7 Hz, 1H), 6.82 (d, J = 8.0 Hz, 1H), 5.97 (s, 2H), 4.24 (q, J = 7.1 Hz, 2H), 2.10 (d, J = 1.6 Hz, 3H),1.33 (t, J = 7.1 Hz, 3H); 13C NMR (100 MHz, CDCl3) d 168.7,147.6, 138.3, 129.9, 126.9, 124.6, 109.5, 108.2, 101.2,  60.7, 14.3,1 4.0; IR (ATR, cm-1): 2981, 2902,1698, 1628, 1502, 1489,1442, 1258, 1224; HRMS (EI) m/z calcd for C13H14O4 (M+) 234.0892, found 234.0895.
Fig The synthetic step of PMK ethyl glycidate

Packaging & Delivery

Packaging Detail: Aluminum foil bag, barrel

Delivery Detail: fast and safe delivery, door to door

Our advantages： 

1.Place of Origin China with Super quality by reasonable price.
2.Fast delivery by safe express way to all the country.
3.Has a number of highly qualified engineers and experts to provide guidance for reagents.
4.When you meet problems in mineral processing, we can provide technical guidance.
5.Sample order are welcome.

FAQ

Q1: What is your MOQ?
Under normal circumstances, MOQ is 1kg, and you can consult customer service for specific products.

Q2:How to contact us?
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Q3: Which kind of payment do you accept?
100%T/T,Western union,Bitcoin,Money Gram,wise and etc.

Q4: How to confirm the Product Quality before placing orders?
1) You can get free samples for some products, just pay the shipping fee for us.
2) Also you can send the specification or your request to us, we will customize the products for you.

Q5: Package
We have standard package, or it can be customized as per your request.

Q6:Shipping
We have R&D and manufactured chemicals for 9 years, we have rich experience on Shipping, Many famous companies cooperated with us stably, we are good at shipping all kinds of chemical products.