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Etomidate CAS 331235-97-2

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Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	391.5±17.0 °C at 760 mmHg
Melting Point	72-74ºC
Molecular Formula	C14H16N2O2
Molecular Weight	244.289
Flash Point	190.6±20.9 °C
Exact Mass	244.121185
PSA	44.12000
LogP	3.26
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.562
Storage condition	2-8°C
Water Solubility	DMSO: >10 mg/mL

Etomidate(R-16659) is a GABAA receptors agonist, which is a short acting intravenous anaesthetic agent used for the induction of general anaesthesia.Target: GABA ReceptorEtomidate is a potent inhibitor of the adrenal response to surgery. The absence of clinical consequences associated with the blunted response suggests that a major increase in adrenal hormone production may not be necessary during surgery [1]. Etomidate is an intravenous induction agent that is associated with hemodynamic stability during intubation. The agent is therefore attractive for use in critically ill patients who have a high risk of hemodynamic instability during this procedure [2]. Etomidate use was not associated with all cause 28-day mortality or hospital mortality but was associated with significantly higher ICU mortality (91% vs. 64% for etomidate and controls groups, respectively; p = 0.02). Etomidate patients who received subsequent doses of hydrocortisone required lower doses of vasopressors and had more vasopressor-free days but no improvement in mortality [3].Clinical indications: FDA Approved Date: 1983Toxicity: Undesirable side effects of etomidate that may limit its use include pain on injection, myoclonus and adrenocortical suppression lasting 4-6 hours following an induction dose.

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Packaging Detail: Aluminum foil bag, barrel

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